Expert-reviewed tumour-to-construct platform

Upload tumour data. Get a reviewed vaccine blueprint dossier.

Advatar mRNA turns paired tumour, normal, RNA, HLA, and pathology data into an auditable neoantigen candidate dossier for molecular tumour boards and licensed GMP manufacturing partners.

Request a dossier See the workflow

Inputs required

tumour, normal, RNA, HLA

Dossier

Primary output

not an automatic treatment

GMP

Release path

licensed partner only

Dossier preview

Evidence-ledger output for expert review

RUO / clinical trial ready

CASE QC

Identity, contamination, RNA quality

Ready

RANKING

Neoantigen evidence and exclusions

Reviewing

BOARD

Expert decisions and signatures

Queued

GMP

Construct package and batch handoff

Locked

Candidate evidence

DNA support, RNA expression, HLA binding, clonality, tumour escape, and uncertainty in one reviewable record.

Controlled export

Locked antigen definitions, checksums, signatures, chain of identity, and GMP partner handoff metadata.

Workflow

Built for review, provenance, and regulated handoff.

The platform creates a defensible bridge between sequencing data, expert biological review, and manufacturing partners. It does not replace clinical judgement, ethics approval, or GMP batch release.

Secure case intake

Create a pseudonymous case, collect consent scope, and validate file checksums before analysis.

Multi-omics evidence ledger

Link every candidate to tumour DNA, matched normal, RNA expression, HLA calls, model versions, and reviewer notes.

Expert tumour board review

Qualified reviewers approve or reject antigens with electronic signatures and locked software versions.

GMP partner package

Export a controlled construct specification for a named licensed manufacturer under a quality agreement.

Online service intake

Prepare a secure upload request.

Submit a case package for review. The first pass validates completeness and prepares a dossier request. Actual analysis, expert approval, GMP manufacture, and release require the named programme controls.

Readiness

0 of 4 files selected, 0 of 3 attestations complete.

The current web prototype keeps selected files in the browser. Production upload storage should only be enabled after encryption, access control, retention, and breach-response policies are configured.

Genome package

Select at least tumour, matched normal, RNA or HLA package, and complete all attestations.

Local preview

Tumour DNANo file selectedVCF, BAM/CRAM, or managed sequencing packageMatched normal DNANo file selectedRequired to separate tumour mutations from inherited variantsTumour RNANo file selectedExpression table, RNA BAM/CRAM, or transcriptomics packageHLA and metadataNo file selectedHLA calls, sample QC, pathology metadata, and consent manifest

I have authority to submit this genomic data for research or clinical review.I understand the output is an expert-reviewed dossier request, not an automatic treatment decision.I understand injectable products require licensed GMP manufacture, QC release, and protocol approval.

Complete required files and attestations.

No direct-to-consumer claims

Built for research groups, clinical-trial sponsors, veterinary specialists, and expert boards.

Privacy by design

Pseudonymous case IDs, consent-aware exports, immutable audit logs, and no consumer AI genomic upload path.

GMP separation

The software exports controlled specifications. Licensed manufacturers remain responsible for production and release.